Biostimulator vs. Filler

Biostimulator vs. Filler

Aesthetic medicine offers several ways to improve the appearance of our skin and minimise the signs of ageing. Among the most popular options are biostimulants and fillers, which can be categorised as minimally invasive injection treatments. But there are differences. In this article, we explain what they are. We also provide an overview of popular biostimulation treatments.

What is biostimulation?

Biostimulation is a medical procedure that aims to stimulate the skin’s natural collagen production. Collagen is a protein that is most abundant in our body. It serves as cell and tissue support and contributes to radiant, smoother skin. Over time, it is broken down in the body, causing the skin to become increasingly saggy and wrinkled. Biostimulation can be used to stimulate collagen formation: The cells regenerate themselves, and older skin cells are replaced with new ones. This is achieved by injecting certain substances that interact with the body’s natural growth factors. The tissue regenerates itself, and the skin appears firmer. Known treatments include:


The Radiesse® treatment can help soften wrinkles and produce smoother facial skin. The filler is calcium-based, and the injection stimulates the production of new collagen in the treated area. Treatment goals include skin tightening and volume building.


The Sculptra® biostimulator consists of poly-L-lactic acid. It stimulates collagen production in the deeper layers of the skin and thus tightens the connective tissue. As a result, wrinkles can also be visibly softened.


UltraCol is based on the biodegradable active ingredient polydioxanone (PDO). In aesthetics, this biostimulator is usually used as a thread material. However, thanks to a new processing method, this carrier substrate can also be used as a filler, creating a natural lifting effect.

PRP treatment:

PRP stands for platelet-rich plasma. A blood sample is taken during PRP treatment. After special preparation, the plasma is injected into the area to be treated, where the growth factors it contains stimulate collagen production. The treatment is also used for hair loss.


HArmonyCA™ combines calcium hydroxyapatite, which stimulates collagen production, with hyaluronic acid. Existing wrinkles can be plumped up from the inside with this treatment, while the biostimulator works in the deeper layers of the skin.

Comparison of biostimulation vs. filler

Biostimulators are also a type of dermal filler. However, there are some differences to traditional fillers.

Mode of action: how do biostimulants and fillers work?

Biostimulants work by stimulating the body’s natural biological processes. They stimulate collagen production, which can make the skin appear firmer and more youthful over time. Fillers, on the other hand, are substances that can create immediate volume and smoothness. Hyaluronic acid is one of the best-known examples.

Advantages and disadvantages: what are the differences between biostimulants and fillers?

The main difference between biostimulants and fillers is that fillers generally have an immediate impact due to their self-filling effect. The desired result is therefore quickly visible. Biostimulants, on the other hand, promote collagen production so that the result only becomes visible after several weeks to months. Our expert Dr Stefan Duve explains this in more detail:


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Fillers and biostimulants are generally very well tolerated. A very natural result can usually be achieved with biostimulants. In many cases, the effect of biostimulants lasts longer.

Application: what are biostimulators and fillers suitable for?

Biostimulants work deep in the skin and are generally used to treat wrinkles, sagging skin and loss of volume. Fillers can be used to fill in wrinkles, improve contours and give lips more volume.

Bottom line: which method is right for me?

A thorough medical history and the patient’s individual needs are particularly important when it comes to choosing the right method. A comprehensive and personal consultation is therefore crucial in order to select the right product from the available wide range.

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